Blar i forfatter "Evjen, Gry"

Viser treff 1-3 av 3

    • Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs 

      Birgisdottir, Åsa Birna; Mouilleron, Stephane; Bhujabal, Zambarlal; Wirth, Martina; Sjøttem, Eva; Evjen, Gry; Zhang, Wenxin; Lee, Rebecca; O'Reilly, Nicola; Tooze, Sharon A; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-04)
      Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1). The latter contains PIK3C3/VPS34, PIK3R4/VPS15, BECN1/Beclin 1 ...

    • SIRT1 is downregulated by autophagy in senescence and ageing 

      Xu, Caiyue; Wang, Lu; Fozouni, Parinaz; Evjen, Gry; Chandra, Vemika; Jiang, Jing; Lu, Congcong; Nicastri, Michael; Bretz, Corey; Winkler, Jeffrey D.; Amaravadi, Ravi; Garcia, Benjamin A.; Adams, Peter D.; Ott, Melanie; Tong, Wei; Johansen, Terje; Dou, Zhixun; Berger, Shelley L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-28)
      SIRT1 (Sir2) is an NAD<sup>+</sup>-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and ageing<sup>1,2,3,4,5</sup>. Although there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly understood. Here we report that macroautophagy (hereafter referred to as ...

    • TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1 

      Zhou, Jianwen; Rasmussen, Nikoline Lander; Olsvik, Hallvard Lauritz; Akimov, Vyacheslav; Hu, Zehan; Evjen, Gry; Kaeser-Pebernard, Stéphanie; Sankar, Devanarayanan Siva; Roubaty, Carole; Verlhac, Pauline; van de Beck, Nicole; Reggiori, Fulvio; Abudu, Yakubu Princely; Blagoev, Blagoy; Lamark, Trond; Johansen, Terje; Dengjel, Jörn (Journal article; Tidsskriftartikkel, 2022-12-27)
      Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory response. Under inflammatory conditions, here TLR3-activation by poly(I:C) treatment, the inflammation ...